Associate Director, Computational Immunology
Company: Tempus AI Inc.
Location: Chicago
Posted on: October 20, 2024
Job Description:
Passionate about precision medicine and advancing the healthcare
industry?
Recent advancements in underlying technology have finally made it
possible for AI to impact clinical care in a meaningful way.
Tempus' proprietary platform connects an entire ecosystem of
real-world evidence to deliver real-time, actionable insights to
physicians, providing critical information about the right
treatments for the right patients, at the right time.
The Associate Director of Computational Immunology in the
Real-World Data Science org will lead and oversee projects
leveraging Tempus' multi-modal database to support specific
biopharmaceutical partners in advancing their drug discovery
portfolio, with a focus on immuno-oncology. This role involves
designing and implementing research studies, analyzing data,
reviewing methods, and providing actionable insights to guide
discovery or decision-making to improve outcomes for biopharma. The
ideal candidate will possess immunology training, experience in
TCR/BCR immune repertoire sequencing, genomic and clinical data
analytical skills, a positive and dynamic leadership style, and the
ability to communicate complex scientific findings to various
stakeholders.
Key Responsibilities:
- Team Management:
- Lead a dynamic team of computational scientists executing
Translational or Real-World Evidence projects integrating molecular
and clinical data from Tempus' multimodal data platform to derive
insights for biopharma partners.
- Establish best practices for reproducibility, help identify
analytical gaps, and suggest next steps.
- Scientific Execution:
- Design, develop, and execute computational immunology research
projects of high complexity.
- Support exploratory research for target discovery and
validation in pre-clinical and early phases of drug
development.
- Support decisions for early-stage assets such as patient and
indication selection, biomarker, and combination
strategies.
- Evaluate clinical trial design by testing assumptions, refining
eligibility criteria, and characterizing patient outcomes on
standard of care.
- Stakeholder Collaboration:
- Work closely with internal teams, including key account
directors, business development, operations, alliance management,
and research informatics, to align team initiatives with broader
business goals.
- Support the development of specific account strategies in
coordination with the account team to expand accounts into
strategic collaborations.
- Reporting & Presentation:
- Oversee the generation of contracted deliverables and executive
summaries for biopharma customers.
- Collaborate with external partners to establish Tempus as a
trusted advisor to expand research partnerships.
- Project Management:
- Work closely with the alliance manager for the execution, and
deliverables of research projects, ensuring that they are completed
on time, within budget, and in accordance with contracted
specifications.
- Continuous Improvement:
- Stay current with industry trends, best practices, and
advancements in computational oncology research.
- Apply this knowledge to enhance research methodologies and
improve overall research quality on the team.
- Become an expert in our biopharma partners' strategy, pipeline,
and portfolio to proactively determine all areas in the Tempus
platform that could add value to the drug development process of
our partners.
- Work with Product and Engineering teams to streamline the
workflow of computational analyses.
- Build relationships with R&D and commercial executives
internally and at partner organizations, enabling identification,
development of, and support for additional value-creation
opportunities.
Qualifications:
- Education: PhD degree in a quantitative discipline (e.g.
Computational Biology, Cancer Biology, Computational Immunology,
Biostatistics/Statistical Genetics, Bioinformatics, or similar).
Alternatively, a PhD in Molecular Biology or Immunology combined
with a very strong record in computational biology.
- Experience: Minimum 4+ years in drug development leveraging
genomic and multimodal data for drug discovery and
development.
- Technical/Scientific Skills: Proficient in R, Python, and SQL.
Strong understanding of Cancer, Immunology, Clinical Trials, and
Real-World Evidence Platforms. Extensive prior experience analyzing
genomic data, including whole exome sequencing, whole transcriptome
sequencing, TCR/BCR immune repertoire sequencing, and particularly
single-cell RNA sequencing.
- Leadership Skills: Demonstrated ability to lead
cross-functional agile teams and manage complex projects. Strong
strategic thinking and problem-solving skills.
- Communication Skills: Excellent written and verbal
communication skills, with the ability to present complex
information clearly and persuasively to diverse audiences.
- Interpersonal Skills: Ability to build strong positive
relationships with internal and external stakeholders.
Collaborative and team-oriented with a high degree of emotional
intelligence and strong negotiation and mentorship skills.
Preferred Skillsets/Background:
- Strong understanding of molecular data and artificial
intelligence in drug discovery with experience in integrative
modeling of multi-modal clinical and omics data.
- Previous experience working with large clinical datasets (EHR,
claims data, clinical trials, patient registries, etc)
- Previous experience working with large transcriptome and NGS
data sets.
- Experience in cancer immunology and TCR-seq
- Prior consulting and/or client-facing experience is highly
desirable
- Thrive in a fast-paced environment and willing to shift
priorities seamlessly.
- Experience with R package development.
- Strong peer-reviewed publication record.
- Experience with: Pandas, NumPy, SciPy, Scikit-learn, Jupyter
Notebooks, RStudio, R Package development, tidyverse, ggplot, Git,
matplotlib, seaborn, HTML5, CSS3, JavaScript, D3, Plot.ly, Flask,
Dask, Docker, AWS.
- Goal orientation, self-motivation, and drive to make a positive
impact in healthcare.
#J-18808-Ljbffr
Keywords: Tempus AI Inc., Gary , Associate Director, Computational Immunology, Executive , Chicago, Indiana
Didn't find what you're looking for? Search again!
Loading more jobs...